Polynucleotides Side Effects: What to Expect

Polynucleotide therapy is redefining what aesthetic treatments can be — regenerative, intelligent, and refreshingly real. At Jorja Aesthetics, we’re not in the business of masking issues. We help your skin heal itself with the power of bio-repair, not band-aids.

But we also believe in truth over trends. So if you’re wondering about the side effects of polynucleotides, we’ve got you — no fluff, just facts.

Like any injectable treatment, polynucleotide therapy comes with short-term, expected responses as your body begins its renewal process. These aren’t problems — they’re proof the treatment is working.

Most Common Side Effects

These are mild, temporary, and often resolve within 24–72 hours. Our Adoreal platform gives you a personalised aftercare plan through your self-serve dashboard, so you’re fully supported at every step.

Are There Any Rare Side Effects?

Rare doesn’t mean never — but at Jorja Aesthetics, we work to reduce even the smallest risks by combining clinical expertise, precise anatomical technique, and evidence-led product choice.

We take your full medical history through our Silhouette Smart Questionnaire before treatment so any potential contraindications are flagged before a needle touches skin.

Why Polynucleotides Are Generally Well-Tolerated

It’s part of what makes this such a powerful option for under-eye rejuvenation, acne-scar repair, rosacea, and more.

The Bottom Line

Side effects are part of the healing process — not something to fear. When you're in experienced, evidence-led hands, polynucleotides offer one of the safest and most transformative paths to real, lasting skin regeneration.

Curious whether it’s right for you? Book your consultation with Jorja Aesthetics — and step into fearless skin recovery.