Polynucleotides Side Effects: What to Expect

Polynucleotide therapy is redefining what aesthetic treatments can be — regenerative, intelligent, and refreshingly real. At Jorja Aesthetics, we’re not in the business of masking issues. We help your skin heal itself with the power of bio-repair, not band-aids.

But we also believe in truth over trends. So if you’re wondering about the side effects of polynucleotides, we’ve got you — no fluff, just facts.

Like any injectable treatment, polynucleotide therapy comes with short-term, expected responses as your body begins its renewal process. These aren’t problems — they’re proof the treatment is working.

Most Common Side Effects

• Redness at injection sites
• Mild swelling or puffiness, especially under the eyes
• Slight bruising (usually gone in 2–3 days)
• Tenderness to the touch for up to 48 hours

These are mild, temporary, and often resolve within 24–72 hours. Our Adoreal platform gives you a personalised aftercare plan through your self-serve dashboard, so you’re fully supported at every step.

Are There Any Rare Side Effects?

Rare doesn’t mean never — but at Jorja Aesthetics, we work to reduce even the smallest risks by combining clinical expertise, precise anatomical technique, and evidence-led product choice.

• Lumps or nodules if the product isn’t massaged properly post-injection (we guide you on this)
• Delayed inflammatory response — your immune system reacting to the DNA fragments (very uncommon)
• Allergic reaction — theoretically possible, but rare due to the purified, biocompatible nature of the product

We take your full medical history through our Silhouette Smart Questionnaire before treatment so any potential contraindications are flagged before a needle touches skin.

Why Polynucleotides Are Generally Well-Tolerated

• They are bioactive, not artificial — your body recognises them as natural healing signals
• The treatment is safe even for sensitive skin
• There’s no volumising or “overfilled” risk
• Side effects are typically gentler and shorter-lived

It’s part of what makes this such a powerful option for under-eye rejuvenation, acne-scar repair, rosacea, and more.

The Bottom Line

Side effects are part of the healing process — not something to fear. When you're in experienced, evidence-led hands, polynucleotides offer one of the safest and most transformative paths to real, lasting skin regeneration.

Curious whether it’s right for you? Book your consultation with Jorja Aesthetics — and step into fearless skin recovery.